Yes, the "Lithograph" T-shirt is designed to be unisex! While it's pre-owned, it's still a classic fit. The size is based on the 9" x 12" design, which is the print size on the shirt. This means a standard adult size. For the best fit, check the measurements of a favorite shirt you already own and compare it to the print size. Remember, it's pre-shrunk, so it should keep its shape wash after wash. We're confident that you'll love it!